Complicated question as the answer can range from "no, that is not a good sign" to "some minor popping can be expected." Simply put, you can get popping in deep vacuum state, and usually from a lean mixture dumping unburned fuel into the exhaust system which then ignites and pops . Think of it this way...during deceleration, in deep vacuum, the mixture of air to fuel has very little gas to it...it is therefore very lean and that mixture does not ignite in the cylinder. That unburnt mixture moves from the cylinder and into the exhaust system. All that unburnt gas can collect and, upon the interminent good ignition in the cylinder, those ignited gases move to the rear exhaust and ignite those unburnt collections...hence the popping. Got a RICH bias and you get alot more popping!
Having said that, more things can be at play. Air leaks can cause it...and, just to make things really complicated, a poorly functioning ignition system can create the conditions for excessive popping as well.
Most high performance cars have some popping. Most folks keep adding bolt on performance imporvements to their Viper...smooth tubes, headers. cat work, hig flo exhausts...and never attend to the fact that the "tune" of their car in open loop is "locked in" by the PCM to stock settings. A good way to limit the effect is to properly tune the car, how do we do that when we have a PCM? Using engine control devices. Will all the popping go away, no, just most of it....and there will be no BANGS whatsoever! In a well sorted car (one that isnt a total monster) the reoccurance of popping is a sign that all is NOT well. By the way, cars with some kind of cat usually experience much less popping.