Low Boost Super charger Vs Heads/Cam packages are totally different beasts, except for the prices and power produced being fairly the same.
The will drive different, sound different, produce totally different driver experiences, make power at different points, and generally be two different animals.
I had a Paxton on my 03, and it drove like a ***** cat until the revs came up. It idle was like stock, and driving at low revs you hardly knew it was there from inside the cockpit. It just ran like a well tuned stock car. When the revs came up, but power built right along with the revs. Great fun, reliable, easy to put back to stock, fairly inexpensive, great fuel economy (unless romping on it) and provided trouble free cruising and blasting for thousands and thousands of miles.
I drove a club members heads/cam package, and it was a totally different beast. It sounded mean, idle was lumpy and felt like it wanted to explode. It had a race car vibe, and let you know you had a monster under the throttle. It revved quickly, and was one of the loudest Vipers i have been in. It fried the tires from throttle tip in until the shift light came on. It guzzled fuel, but the payback was super throttle response, and the ability to shred tires at your command.
Now others have different packages with their own setups, but this has been my experience.
The Gen IV's and V's do not currently have easy supercharger availability, however lots of tuners offer significant power increases and run up the fun factor with heads, cams, intakes and exhaust systems that will give you all the throttle your tires and suspension can cope with.