I've taken the block plugs out of 2 different 1996 Vipers and while they all "snap" a bit when they loosen, I did not fear damage. Quite a bit of coolant was trapped up there. Big deal if you don't remove? Probably not.
On the other hand as Steve mentions, the thermostat air bleed is way too tight (and the head is too small to get enough torque on it anyway) to risk removal unless the housing is off for a thermostat change. I've only heard of one person that has successfully removed it while on the car. Careful refill, burping and starting practice eliminates the need anyway. The upper hose bleeder helps with the burping but does not free the air trapped under the thermosat. That is only removed via the thermostat bleeder or when the thermostat opens. The problem is that the air trapped under the pellet delays the opening until you're in an near overheat situation. Shutting the engine down after warm up and then letting the heat soak open it solves the issue.
The culprit is not the age (first 1996 was 4 years old, second was 6 when plugs were first removed) or the plug itself, but a brown thick locktite type sealer that is way over applied. I reinstalled the block plugs with antiseize and then added a dab of silicone seal on the head of the plug smeared over to the block. Just enough to prevent vibration from backing it out. 10K miles later, perfect.
As Dean states, the radiator plug is probably the most dangerous to remove the first time. Very flimsy area of the tank.....