It's a good safety tip to run 1-2 heat ranges colder spark plugs with a 150 shot. You don't need to retard timing, but I chose to run a window switch instead on manual nitrous activation for safety. And make sure to do dyno tuning to dial in a safe A/F ratio (and to optimize the power).
It's not that the halfshafts are weak, it's just when you really crank up the torque past
600 RWTQ something has got to give.
I run on street tires, so it's the tires spinning that takes up the extra energy, but if you run drag radials then the car will hook right up and either the halfshafts (U-joints), the clutch, the differential, or the transmission will be taking that powerful shock. And you have to decide what you want to break under that load.
On many cars the Viper's drivetrain can take the abuse OK, but if you get wheelhop then things can break quickly.