My thoughts were that these paints have already been used for years by the OEM's.
In particular, Viper has a paint that is compliant - it is not a hard paint. The result is that debris that leaves a stone chip on a hard, conventional paint merely bounces off Viper. I had a 98 Z28 black convertible and I assure you, every grain of sand that hit that front end left a white fracture surface in the clear coat. My 2000 Viper I put 16k miles on it had something like 5 stone chips. (granted it was red and not black but I would scrutinize it on my hands and knees periodically.)
Perhaps D-C uses a flex agent in the clear or maybe it is a characteristic of water based paint.
There there are diisocyanates.
Ironically, zero tolerance VOC policy, while supposedly to the health of community, exposes auto paint professionals' lives to greatly increased hazardous risk.
I don't mind if some inhaled toxin builds in in my liver and kidneys and is never eliminated from my body. A good respirator works just fine.
DI's are that an all this: they are absorbed thru your skin and eyes and you can be come sensitized to them. That is a real show stopper for me personally.
I do my painting in a highly ventilated/filtered garage in my residential neighborhood and would welcome less hazardous, stinky materials. My ventilation flow volume is so great, you smell nothing if you are upwind from the gun. I've had great results with this high velocity.
My guess is that the water based stuff is much less toxic and offensive.
If that is the case, I say bring it on - especially since I never made the transition to the modern basecoat/clearcoats and I'd just as soon skip them entirely if possible.