As far as blueprinting, it does nothing as far as power is concerned. It only comes into play when you blow an engine so you can rebuild the exacte duplicate of the motor.
Mopar - I have no axe to grind... but guys like you I loved the most in the speed game. I always knew you'd be back to replace all the bits that I knew would break - I'd of course always tell my customers in advance - but only a few listened - and those ones went very fast and reliably.
Blue printing will add more hp than any other single bolt on to the old muscle car engine - but more important than that - your engine will actually get a chance to live at the rpms and power levels you are talking. If you have heard different - you've heard wrong. There's 50 hp in the bore prep alone without even looking at a multi angle valve job etc.
600hp 427 from bolt ons alone and no blueprinting or balance is BS on anything that could run power brakes - no offence - but what will happen is that you will bolt on your hot bits - go to the track and either ponder why the trap speeds are not what 600hp calculators told you they should be - or you'll throw a leg out of bed trying to reach them. You at least need to prep the rods, run ARP rob bolts, balance the engine and torque plate hone the bores - then you will have a chance. Ignore the friendly advice at your own risk.
If it does survive - congrats - there's always an exception, you will still be short of a genuine 600hp - but it'll feel so fast you'll swear it has got it and find excuses why it does not run 125mph on the 1/4
Your money - do what you want. I'd save my money and build a great BP and Bal engine with good heads, rods and pistons and rings etc - then you can go make the real power. There's 600hp over a beer, and there's 125mph+ down the 1/4 mile 600hp - which one do you want?
re relative strenghts of old vs new. Cast pistons in the later V10's mean nothing - they'll take serious power provided there is low boost and no detonation. They can be replaced - you wouldn't be running stock pistons/rods in a 800hp big block either. The 4 bolt mains etc are all fine - but you'll find blocks giving out around 600-800hp on all of them over time - except the Hemi which was very strong (and heavy). If the blocks held - the stock rods won't - the drag strips are covered in Chevy and Ford rod memories - every single strip there is has many such memories. They had poor rod stroke ratios or weak rods or both. Stock V10 bottom ends have seen 1000lb ft of torque and are driven daily - ask Tom at BTR. Outside the Hemi - I'd like to see you try that on any of the old stock bottom ends - blue-printed or not.
If you want to spank a stock Viper with a good driver on 255 tires - you'll need more than a few bolt ons. You'll also need diapers because once you get 600 real hp on those tires - you'll be in for some thrills. Good luck on your project.